Zona Pellucida Glycoproteins
نویسندگان
چکیده
منابع مشابه
1 Zona Pellucida Glycoproteins
Abbreviations: ZP, zona pellucida; ZPG, ZP glycoprotein; VE, vitelline envelope; VEG, VE glycoprotein; mZP, mouse ZP; hZP, human ZP; SS, signal sequence; CTP, C-terminal propeptide; CFCS, consensus furin cleavage-site; TMD, transmembrane domain; ZPD, ZP domain; NTS, N-terminal subdomain; CTS, C-terminal subdomain; EHP, external hydrophobic patch; IHP, internal hydrophobic patch; CP, charged pat...
متن کاملCharacterization of human zona pellucida glycoproteins.
The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptides predicted from the human ZP2 and ZP3 cDNA, we identified ZP3 as a 53-60 kDa...
متن کاملAcrosome reaction: relevance of zona pellucida glycoproteins.
During mammalian fertilisation, the zona pellucida (ZP) matrix surrounding the oocyte is responsible for the binding of the spermatozoa to the oocyte and induction of the acrosome reaction (AR) in the ZP-bound spermatozoon. The AR is crucial for the penetration of the ZP matrix by spermatozoa. The ZP matrix in mice is composed of three glycoproteins designated ZP1, ZP2 and ZP3, whereas in human...
متن کاملNative human zona pellucida glycoproteins: purification and binding properties.
BACKGROUND Fertilization starts with the binding of the spermatozoa to the zona pellucida (ZP) of the oocyte. Such binding is a carbohydrate-mediated event and consists of a series of tightly regulated events. Molecular interactions between spermatozoon and ZP in human are not well characterized due to limited availability of oocytes for research. Our current technology cannot generate recombin...
متن کاملFour zona pellucida glycoproteins are expressed in the human.
BACKGROUND The zona pellucida (ZP) is an extracellular glycoprotein matrix which surrounds all mammalian oocytes. Recent data have shown the presence of four human zona genes (ZP1, ZP2, ZP3 and ZPB). The aim of the study was to determine if all four ZP proteins are expressed and present in the human. METHODS cDNA derived from human oocytes were used to amplify by PCR the four ZP genes. In add...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.r800027200